Overview of N,N-Dimethyltryptamine

N,N-Dimethyltryptamine (also known as DMT, N,N-DMT, Dmitri, and "The Spirit Molecule") is a classical psychedelic substance of the tryptamine class.

Among psychedelics, it is known for its unique ability to produce short-lived but intense visionary states and complete hallucinations. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood.

DMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout the plant kingdom.

Although various theories have been postulated, its neurobiological function has yet to be determined.

When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an "inconceivably high-speed rollercoaster ride." When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature: this combination is known as ayahuasca.

Ayahuasca brews have been used traditionally in South America since at least around the year 1500.

Unlike most highly prohibited substances, DMT has not been proven to be addictive or physiologically toxic.

However, adverse reactions such as severe anxiety, delusions and psychosis are always possible, even for experienced users, and particularly for those predisposed to mental disorders.

DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the "business trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms.

DMT can be inhaled, ingested, or injected and its effects depend on the dose, as well as the chosen mode of administration. When inhaled or injected, the effects last a short period of time: about five to 15 minutes. Effects can last three hours or more when orally ingested along with an MAOI, such as the ayahuasca brew of many native Amazonian tribes.

DMT can produce vivid "projections" of mystical experiences involving euphoria and dynamic hallucinations of geometric forms.

DMT is a functional analog and structural analog of other psychedelic tryptamines such as O-acetylpsilocin (4-AcO-DMT), 5-MeO-DMT, psilocybin (4-PO-DMT), psilocin (4-HO-DMT), and bufotenin (5-HO-DMT). The structure of DMT occurs within some important biomolecules like serotonin and melatonin, making them structural analogs of DMT.

It is highly advised to use harm reduction practices if using this substance.